甲状腺球蛋白浓度的变化对鉴别良性和恶性甲状腺结节的临床价值

Determination of Thyroglobulin for Detecting Property of Thyroid Nodule

目的动态观察甲状腺球蛋白(Tg)浓度变化对鉴别良、恶性甲状腺结节的临床价值。方法62例甲状腺结节患者根据术后病理诊断分为2组,恶性组29例,良性组33例。分析术前Tg浓度动态变化规律,比较Tg与B超鉴别甲状腺结节的临床价值。结果Tg初诊与术前水平,恶性组[(126.8±46.2)vs(164.6±77.3)ng/mL,P<0.01],良性组[(53.6±38.9)vs(44.8±37.6)ng/mL,P>0.05]。Tg变化对甲状腺恶性结节的预测性与B超相仿。结论动态观察Tg对鉴别甲状腺结节良、恶性有较高的临床价值。Tg与B超联合可提高诊断的准确率及灵敏度。

Objective To study the value of changes of thyroglobulin in detecting property of thyroid nodule. Methods 62 patients with thyroid nodule, divided into two groups（malignant 29, innocent 33） according to pathology. Serum thyroglobulin determined with chemiluminescence method. Results Thyroglobulin of malignant group ： preliminary diagnosis （ 126.8± 46.2） ng/mL, pre-operation （164.6± 77.3）ng/mL were higher than the innocent group （53.6-4-38.9）ng/mL. The predictability of thyroglobulin of malignant thyroid nodule were similar to B-ultrasonogram. There maybe higher sensitivity and accuracy if they combinated. Conclusion Changes of thyroglobulin is well used in detecting property of thyroid nodule.