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^(99m)Tc-MIBI显像及定量分析定位诊断甲状旁腺腺瘤的临床应用 被引量：3

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摘要 目的根据高功能甲状旁腺对MIBI摄取增高的原理,应用SPECT和平面显像定量分析评价术前定位原发性甲旁亢的诊断价值。方法对21例原发性甲旁亢患者采用99mTc-MIBI平面双时相显像及定量分析作术前定位;其中4例加作SPECT断层显像。检测所有病人血清PTH水平及血清钙水平。定量分析采用靶甲状旁腺腺瘤与最大甲状腺放射性(ROI)平均计数比率和靶甲状旁腺腺瘤(T)与对侧相应甲状腺(NT)比值计算。结果双时相平面显像的敏感性为81%(17/21);其中4例平面显像假阴性者2例经SPECT断层获得阳性定位(1例异位腺瘤、1例腺瘤虽然位置正常但同时存在多发结节性甲状腺肿);另2例假阴性者为位置正常但摄取99mTc-M IB I低的腺瘤。甲状旁腺腺瘤对最大甲状腺放射性计数的平均摄取比值和T/NT比值分别为0.95±0.41和2.51±1.76。结论99mTc-MIBI显像是最有效的探测甲状旁腺腺瘤的方法;对探测异位性甲状旁腺腺瘤或同时存在多发结节性甲状腺肿时SPECT断层的敏感性比平面显像更高。
作者 谢天豪 叶万忠 范益军 沈国平 赵燕 王石红
机构地区 江苏省原子医学研究所临床核医学科
出处 《中国辐射卫生》 北大核心 2007年第4期477-479,共3页 Chinese Journal of Radiological Health
关键词 甲状旁腺功能亢进 甲状旁腺 放射性核素显像 MIBI
分类号 R817 [医药卫生—影像医学与核医学]
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参考文献13

  • 1LORBERBOYM M, MINSKI I, MACADZIOB S, et al: Incremental diagnostic value of preoperative ^99mTc - MIBI SPECT in patients with a parathyroid adenoma [ J ], J Nucl Med, 2003,44:904 - 908.
  • 2HOWE J R. MINIMALLY INVASIVE parathyroid surgery [J]. Surg Clin North Am, 2000,80:1399 -1426.
  • 3INABNET W B, FULLA Y, RICHARD B, et al. Unilateral neck exploration under local anesthesia: the approach of choice for asymptomatic primary hyperparathyroidism [ J ]. Surgery 1999,126 : 1004 - 1009.
  • 4RUBELLO D, PIOTTO A, PAGETTA C, et al. Ectopic parathyroid adenomas located at carotid bifurcation: the role of preoperative Tc - 99m - MIBI scintigraphy and the intraoperative gamma probe procedure in surgical treatment planning [J]. Clin Nucl Med. , 2000,26:774-776.
  • 5ROTHMUND M, DIETHELM H, BRUNNER H, et al. Diagnosis and surgical treatment of mediastinal parathyroid tumors[J]. Ann Surg, 1976,183:139 - 145.
  • 6STAUDENHERZ A, NIEDERLE B, ABELA C, et al. Comparison and histopathologieal correlation of three parathyroid imaging methods in a population with a high prevalence of concomitant thyroid diseases [ J ]. Eur J Nucl Med, 1997 24:143 - 149.
  • 7ODOHERTY M J , KETTLE A G, WELLS P, et al. Parathyroid imaging with technetium - 99m - sestamibi : preoperative localization and tissue uptake studies [ J ]. J Nucl Med, 1992,33:313 - 316.
  • 8BILLOTEY C, SARFATI E, ARENGO A, et al. Advantages of SPECT in 99Tcm - sestamibi parathyroid scintigraphy [J]. J Nucl Med 1996;37:1773 -1778.
  • 9TAILLEFER R, BOUCHER Y, POTVIN C, et al. Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with technetium - 99m - sestamibi ( double - phase study) [J]. J Nucl Med, 1992,33:1801 -1807.
  • 10CASARA D,RUBELLO D, PIOTTO A, et al. ^99mTc - MI- BI radio - guided minimally invasive parathyroid surgery planned on the basis of a preoperative combined ^99mTc - pertechnetate / ^99mTc - MIBI and ultrasound imaging protocol[ J ].Eur J Nucl Med, 2000,27 : 1300 - 1304.

同被引文献31

  • 1周建平,李晓莉,董明,郭克建,田雨霖.我国原发性甲状旁腺功能亢进症的误诊情况分析[J].中国现代医学杂志,2006,16(7):1040-1042. 被引量：50
  • 2魏晓峰,杜涛,周菊.甲状旁腺功能亢进症^(99m)Tc-MIBI核素显像14例分析[J].中国误诊学杂志,2007,7(6):1320-1320. 被引量：2
  • 3Calva-Cerqueira D, Smith BJ, HostetlerML, etal. Minimally invasive parathyroidectomy and preoperative MIBi scans: correlation of gland weight and preoperative PTH[J]. J Am Coll Surg, 2007 , 205(4 Snppl):S38-44.
  • 4Palestro CJ, Tomas MB, Tronco GG. Radionuclide imaging of the parathyroid glands[J]. Semin Nucl Med, 2005, 35 (4) : 266- 276.
  • 5Swanson TW, Chan SK, Jones SJ, et al. Determinants of ^99Tc^m sestamibi SPECT scan sensitivity in primary hyperparathyroidism [J]. Am J Surg, 2010,199(5) : 614-620.
  • 6Muros MA, Bravo Soto J, Lopez Ruiz JM, etal. Two-phase scintigraphy with technetium ^99m-sestamibi in patients with hyperparathyroidism due to chronic renal failure[J]. Am J Surg, 2007,193 (4): 438-442.
  • 7Fraser WD.Hyperparathyroidism.Lancet,2009,374:145-158.
  • 8Chen HH,Chen YW,Wu CJ.Primary hyperparathyroidism in Taiwan:clinical features and prevalence in a single-center experience.Endocrine,2010,37:373-378.
  • 9Oliveira UE,Ohe MN,Santos RO,et al.Analysis of the diagnostic presentation profile,parathyroidectomy indication and bone mineral density follow-up of Brazilian patients with primary hyperparathyroidism.Braz J Med Biol Res,2007,40:519-526.
  • 10Kandil E,Alabbas H,Tufaro AP,et al.The impact of baseline intact parathyroid hormone levels on severity of primary hyperparathyroidism and outcomes in patients undergoing surgery.Arch Otolaryngol Head Neck Surg,2010,136:147-150.

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中国辐射卫生
2007年 第4期

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