双黄连粉针剂抗乌头碱诱发大鼠心律失常的实验研究

目的:观察双黄连粉针剂对抗乌头碱诱发大鼠实验性心律失常的作用。方法:静脉注射乌头碱复制大鼠心律失常动物模型,在预先静脉注射双黄连粉针剂60mg/kg、30mg/kg的基础上,观察其抗乌头碱诱发大鼠实验性心律失常的作用。结果:双黄连粉针剂可明显提高乌头碱致大鼠发生VP、VT、Vf的阈值。结论:双黄连粉针剂具有一定抗乌头碱致大鼠实验性心律失常的作用。

Objective：To observe the anti-arrhythmic effects of injection Shuanghuanglian on the experimental arrhythmic models produced by intravenously injecting aconitine. Methods：Reproduce the experimental arrhythmic models by intravenously injecting aconitine,injection Shuanghuanglian （60mg/kg,30mg/kg）were precautionary intravenously injected respectively,observed the anti-arrhythmic effects,Result：Injection Shuanghuanglian could significantly increase the dosages of aconitine inducing VP.VT,Vf in rats, Conclusion： Injection Shuanghuanglian exerteded anti-arrhythmic effects on the experimental arrhythmic models produced by intravenously injecting aconitine.