胃癌术后辅助化疗研究进展

Advances in adjuvant chemotherapy for gastric cancer

辅助化疗是在根治性手术后减少局部和远处复发的方法。其中，术后辅助化疗包括全身化疗、腹腔灌注化疗。新一代的化疗药物卡培他滨、奥沙利铂、紫杉醇、依立替康、S—1等显示出很好的治疗前景，化疗敏感试验的开展可能有助于个体化化疗方案的制定。腹腔灌注化疗有助于降低腹腔局部复发。

Adjuvant Chemotherapy is given after a radical resection to reduce or eliminate the possibility of local and distant recurrence. Adjuvant chemotherapy includes systemic chemotherapy and intraperitoneal therapy. Capecitab, paclitaxel, oxaliplatin irinotecan and S-1 have shown promising results. Chemosensitivity test may be usefulfor individualized chemotherapy. Intraperitoneal therapy can improvethe treatment of microscopic residual disease.