期刊文献+

罗格列酮治疗2型糖尿病合并脂肪肝疗效观察 被引量:2

The effects of rosiglitazone in treatment of type 2 diabetes mellitus-complicated fatty liver
下载PDF
导出
摘要 对2型糖尿病(T2DM)合并脂肪肝的患者122例,分成RSG治疗组和对照组。观察6个月。RSG治疗组在改善脂肪肝程度、降低空腹胰岛素及改善肝功能等方面明显优于对照组。 122 patients with type 2 diabetes mellitus-complicated fatty liver were assigned to two groups: the study group with rosiglitazone (RSG) treatment and the control group without rosiglitazone treatment. The change in fatty liver of the patients in both groups were recorded and compared. Based on six months observation, ;the patients with RSG treatment showed a significant improvement as compared with the control group in terms of reduction of fatty liver, reduction of fasting insulin (Fins)and improvement of liver functions.
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2007年第11期672-673,共2页 Chinese Journal of Diabetes
关键词 糖尿病 2型 脂肪肝 非酒精性 代谢综合征 罗格列酮 Diabetes mellitus, type 2 Fatty liver, nonalcoholic Metabolism syndrome Rosiglitazone
  • 相关文献

参考文献7

二级参考文献38

  • 1[1]Li AC, Brown KK, Silvestre MJ, et al. Peroxisome proliferator-activated receptor γ-ligands inhibit development of atherosclerosis in LDL receptor-dificient mice. J Clin Invest,2000,106:523-531.
  • 2[2]Minamikava J, Tanaka S, Yamauchi M, et al. Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab,1998,83:1818-1820.
  • 3[3]Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care,2001,24:683-689.
  • 4[4]Saltiel AR, Olefsky JM. Thiazolidinediones in the treatment of insulin resistance and type Ⅱdiabetes. Diabetes,1996,45:1661-1669.
  • 5[5]Yang C, Chang TJ, Chang JC, et al. Rosiglitazone(BRL 49653) enhances insulin secretory response via phosphatidylinositol 3-kinase pathway. Diabetes,2001,50:2598-2602.
  • 6[6]Oakes ND, Thalén PG, Jacinto SM, et al. Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability. Diabetes,2001,50:1158-1165.
  • 7[7]Murakami K, Tobe K, Ide T, et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma:effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats . Diabetes,1998,47:1841-1847.
  • 8[8]Combs TP, Wagner JA, Berger J, et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARγ agonists: A potential mechanism of insulin sensitization. Endocrinology,2002,143:998-1007.
  • 9[9]Walker AB, Chattington PD, Buckingham RE, et al. The thiazolidinedione rosiglitazone(BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats. Diabetes,1999,48:1448-1453.
  • 10[10]Nordt TK, Peter K, Bode C, et al. Differential regulation by troglitazone of plasminogen activator inhibitor type 1 in human hepatic and vascular cells. J Clin Endocrinol Metab,2000,85:1563-1568.

共引文献417

同被引文献7

引证文献2

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部