双途径介入治疗肝癌的疗效观察

Clinical Effect of Combination of Two Kinds of Interventional Treatment on Hepatocellular Carcinoma

目的评价综合应用肝动脉灌注化疗栓塞术（TACE）和经皮穿刺瘤内无水乙醇注射术（PEI）治疗肝癌的，1名床效果。方法60例原发性肝癌随机分为2组：TACE＋PEI组（n=32）先行肝动脉化疗栓塞（TACE），1周内再于瘤体内注射无水酒精，每周1—2次；TACE组（n=28）单纯行肝动脉化疗栓塞术。两组病例均每4—6周重复行TACE，每例治疗2—4次。结果TACE＋PEI组肿瘤治疗的有效率为68．8％，TACE组肿瘤治疗的有效率为39．3％。TACE＋PEI组和TACE组甲胎蛋白（AFP）下降率分别为75％、46．4％，2年生存率分别为35％、21％，差异均有显著性（P〈0．05）。结论综合应用肝动脉化疗栓塞术和经皮穿刺瘤内无水乙醇注射是治疗肝癌的有效方法。

Objective To evaluate curative effect of treating the hepatecellular carcinoma（HCC）using a combination of transcatheter arterial chemoembolization（ TACE ） and percutaneous ethanol injection（ PEI ）. Melhods 60 patients with HCC were randomized into two groups, TACE ＋ PEI group （ 32 cases ） were administered with transcatheter arterial chemoembolization, then PEI within 7 days after TACE. TACE group（28 cases）were given with transcatheter arterial chemoembolization only. The treatment was repeated every 4 - 6 weeks and every patient was treated 2 to 4 times in the two groups. Results The overall response rate was 68.8% in TACE ＋ PEI group and 39.3% in TACE group;the decline rate in serum AFP level was 75 % ,46.4% ; The two-year survival rates were 35%, 21% respectively. Significant differences were found between two groups（ P 〈 0.05）. Conclusion Combination of TACE and PEI is an effective treatment for hepatocellular carcinoma.