芳香醛(酮)缩氨基硫脲的微波合成及其抗菌活性的研究

Synthesis of thiosemicarbazones under microwave irradiation and their antibacterial activity

肼基二硫代甲酸甲酯与相应的醛或酮在微波辐射下经2～3．5min反应，得到3-二取代甲（乙）撑肼基二硫代甲酸甲酯，产率91％～96％。再与胺在微波辐射下经35～45min反应，得到目标化合物，产率80％～90％。合成的6个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析，对其结构进行确证，并测试了化合物的抑菌活性。

Six thiosemicarbazones were synthesized. Under microwave irradiation, methyl hydrazinecarbodithioate was reacted with ketone or aldehyde in i-PrOH to form intermediate compounds （3-disubstituted methyl hydrazinecarbodithioate） with 91% -96% yield respectively （in 2 - 3.5 min）. Intermediate compounds were reacted with N^4-substituted piperazine and morpholine in ethanol to form thiosemicarbazones with 80% - 90% yield （in 35- 45 min）.The structures of these compounds have been confirmed by means of their IR, ^1HNMR, and mass spectra. The antibacterial activities of the compounds have been tested against three kinds of bacteria. The results showed that the compounds possess different inhibitive effects.