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血管紧张素原基因T704C多态性与血脂水平及原发性高血压的相关性探讨 被引量：2

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摘要 采用PCR-RFLP方法检测开滦煤矿汉族人群(1 224例)血管紧张素原(AGT)基因T704C单核苷酸多态性;用全自动生化分析仪测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)水平,分析AGT基因T704C多态性与血脂水平及原发性高血压(EH组)的相关性。结果非EH(NEH组,1004例)携带CC基因型者血清TG、VLDL水平显著高于携带TT、TG者,携带TT基因型者HDL水平高于携带TC和CC基因型者(P均<0.05);EH组携带TT基因型者TC、TG、VLDL水平高于NEH组,HDL含量低于NEH组,携带TC基因型者TC、TG、LDL、VLDL水平高于NEH组,P均<0.05。认为AGT基因T704C多态性与EH发病有关,可能机制为影响血脂水平。
作者 沈志霞 李宏芬 王菊惠 任燕 吴寿岭
机构地区 华北煤炭医学院附属开滦医院
出处 《山东医药》 CAS 北大核心 2007年第35期55-56,共2页 Shandong Medical Journal
关键词 血管紧张素原基因 原发性高血压 血脂
分类号 R181.32 [医药卫生—流行病学]
  • 相关文献

参考文献6

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共引文献2

同被引文献20

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二级引证文献4

山东医药
2007年 第35期

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