nm23-H_1在急性白血病患者血浆中的表达及其临床意义

Plasma level of the differentiation inhibitor nm23-H_1 protein and its clinical implications in acute leukemia

目的检测分化抑制因子nm23-H1蛋白在急性白血病(AL)患者血浆中的表达水平,探讨其临床意义。方法采用酶联免疫吸附法测定nm23-H1蛋白在100例AL患者和30例健康志愿者(对照组)血浆中的水平。结果nm23-H1在初治AL患者中明显高于健康志愿者,在急性髓系白血病各亚型中M6患者的nm23-H1血浆水平最高,M3患者水平最低。持续完全缓解的AL患者nm23-H1血浆水平与对照组无统计学差异。结论nm23-H1血浆蛋白水平可能是判断AL患者预后的一种标志。

[ Objective] To detect the plasma level of nm23-H1 protein in patients with acute leukemia （AL） and analyze its clinical significance. [ Methods] The plasma level of differentiation inhibitory factor nm23-H1 protein was measured by ELISA method in 100 AL patients and 30 healthy volunteers. [ Results] nm23-H1 protein level in the plasma of AL patients was higher than that in volunteers. The average plasma level of nm23-H1 protein was the highest in M6 patients and the lowest in M3 patients. There was no statistical difference in the plasma levels of nm23-H1 protein between AL patients with complete remission and healthy volunteers. [ Conclusion] The plasma level of nm23-H1 protein may be used as a predicator of outcome in AL patients.