皮康外洗液的药效学初步研究

Preliminary pharmacodynamic study of Pikang wash liqid

目的:探讨皮康外洗液的抗炎、抗过敏及抗菌作用。方法:采用抗炎实验、迟发性过敏反应、体外抑菌试验等方法进行研究。结果:皮康外洗液对二甲苯诱导的小鼠耳廓肿胀及2,4-二硝基氟苯诱导的小鼠迟发性过敏反应均有明显抑制作用,对豚鼠脱毛区皮肤无刺激反应,抑菌实验表明对绿脓杆菌、金黄色葡萄球菌等多种致病菌有一定的抑制作用。结论:皮康外洗液具有较好的抗炎及抗菌作用,且对皮肤无刺激,本研究为该药治疗小儿皮肤病提供了初步的药效学资料。

Objective： A preliminary study of anti-inflammatory, anti-allergic and antibacterial activities of Pikang wash liquid. Methods： The studies were carried out by means of anti-inflammatory experiments, delayed hypersensitivity and vitro test of inhibitory bacteria. Results： Pikang wash liquid had markedly inhibitory effect on the ear swelling induced with xylene in mice and the delayed hypersensitivity reaction induced with 2,4-dinitrofluorobenzene. There was no irritant reaction on guinea pig skin and in tests of inhibitory bacteria, a certain inhibitory effect on aeruginosns Bacillus and staphylococcus amens and other germs were found. Conclusions： Pikang wash liquid has a good function in anti-inammatory and antibacterial but no irritant to the skin. This study provided preliminary pharmacedynamics data to cure infant dermatosis with this drug.