大剂量氨溴索预防早产儿肺透明膜病疗效分析

Effect of high dosage of ambroxol on prevention of Hyaline membrane disease in premature newborns

目的:探讨大剂量氨溴索预防早产儿肺透明膜病(HMD)的疗效。方法:将126例发生肺透明膜病早产儿分为预防组和对照组,对照组58例给予常规治疗,预防组68例在常规治疗的基础上应用氨溴索,观察两组早产儿肺透明膜病及并发症的发生率,监测入院6 h血气分析结果并进行比较。结果:对照组和预防组HMD的发生率(χ2=6.54,P<0.05)、入院6 h血气分析结果(P<0.05)、并发症发生率(P<0.05)比较差异均有统计学意义。结论:早期应用大剂量氨溴索预防早产儿肺透明膜病有较好疗效,适合基层医院推广应用。

Objective： The prospective study was designed aiming at determining the effect of high dosage of ambroxol in preventing of hyaline membrane disease of premature newborns. Methods： Those premature newborns who were treated with ambroxol were in the prevention group （68 cases） and those not were in the control group （58 cases）. The incidences of HMD and the incidences of complications between two groups were compared. The blood gas analysis within 6 hours after hospitalization between two groups were measured and compared. Results： The incidences of HMD between two groups were significantly different （ P 〈 0.05 ）. The results of blood gas analysis between two groups were also significantly different （ P 〈 0.05 ）. The incidences of complications between two groups were still significantly different （ P 〈 0.05 ）. Conclusions： Early administration of high dosage of ambroxol is effective in prevention of HMD and is worth promoting in clinic practice.