蒙古族人群胰岛素抵抗与心血管病关系

Relationship of insulin resistance with cardiovascular disease among Mongoalian people

目的探讨蒙古族人群中胰岛素抵抗与心血管病危险因素水平及其聚集性的关系。方法对1 090名蒙古族成年人进行血压、身高、体重、腰围及臀围的测量和血糖、胰岛素、血脂的检测。按照胰岛素抵抗指数水平由低到高将全部研究对象等分为4组,比较4组间各危险因素及其聚集性差异。结果调整年龄、性别因素后,体质指数、腰臀比、收缩压、舒张压、甘油三酯、空腹血糖及高血压患病率均随着胰岛素抵抗指数的水平增高而上升(P<0.05)。在调整年龄和体质指数后,胰岛素抵抗指数与腰臀比、收缩压、甘油三酯呈显著正相关。具有≥2个危险因素的个体所占百分比随着胰岛素抵抗指数增高而增高,在4组的比例分别为33.8%,44.5%,47.2%和66.5%(χ2=60.265 7,P<0.000 1)。结论胰岛素抵抗与多种心血管病危险因素具有相关性,并影响多种心血管病危险因素水平,增加其聚集强度。

Objective To explore the relationship of insulin resistance with risk factors of cardiovascular disease and their clustering in Mongolian people. Methods 1 090 subjects were investigated for blood pressure, height, weight, waistline, hipcircum, and their blood specimens were collected for glucose, insulin and serum lipids analysis. The whole subjects were divided into 4 groups according to their insulin resistance index（IR） level, and compared differences in risk factors and the clustering of risk factors between groups. Results After being adjusted for age and gender, BMI, WHR, SBP, DBP, TG, FPG and prevalence of essential hypertension increased with the raise of IR, P 〈 0.05. IR had correlations with WHR, SBP, and TG. The rates of clustering of cardiovascular diseases risk factors from the lowest to the highest quartile groups of IR level were 33.8 %, 44.5 %, 47.2 %, 66.5 %, respectively（χ^2 = 60. 265 7, P 〈 0. 000 1 ）. Conclusion Insulin resistance was correlated with several cardiovascular diseases risk factors and increased their level and clustering.