IGF-1、HIF-1a在肝细胞肝癌中的表达及其临床意义

Expression of IGF-I and HIF-1αin Hepatocellular Carcinoma and Its Clinical Significance

目的:研究胰岛素样生长因子-1(IGF-1)、低氧诱导因子-1α(HIF-1α)在肝细胞肝癌(HCC)中的表达及其意义。方法:采用免疫组织化学SABC法检测54例HCC及14例正常肝组织中IGF-1和HIF-1α的表达情况,研究其与HCC生物学行为的关系。结果:54例HCC中IGF-1、HIF-1α的表达均较正常肝组织高,差异具有显著性(χ2=9.112,13.369;P<0.05)。HCC中IGF-1与HIF-1α的表达呈正相关(rs=0.539,P<0.05)。HIF-1α的表达与肿瘤的侵袭转移密切相关(P<0.05),IGF-1在AFP≥400μg/ml的HCC组织中表达明显高于AFP<400μg/ml者,差异具有显著性(P<0.05)。结论:HCC中IGF-1和HIF-1α表达反映HCC的生物学行为,可作为预测肝癌浸润转移的一项重要指标。

Objective：To investigate the expressions of IGF-Iand HIF 1α in hepatocellu1αr carcinoma （HCC） and their clinical significance. Methods：The expressions of IGF-I and HIF-1α in 54 cases of HCC and normal liver tissues were studied by immunohistochemistry assay. Results：The expressions of IGF-I and HIF-1α protein in hepatocellu1αr Carcinoma was significantly higher than in normal livertissues（X2= 9. 112,13. 369 ;P〈0. 05）. The expression of HIF-1α was positively associated with IGF-1 （rx = 0. 539 ,P〈0.05）. The expression of HIF-1α was significantly corre1αted with ability of invasion and metastasis. The expressions of IGF-I protein in HCC with AFP ≥400μg/ml were significantly higher than in HCC with AFP≥400 μg/ml. Conclusion：The expressions of IGF-I and HIF-1α can reflect the biological behavior of HCC. they are important indexes for HCC invasion and metastasis.