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Taurolidine通过诱导小鼠黑色素瘤(B16-4A5)细胞凋亡提高放射敏感性临床观察 被引量：1

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摘要 目的:Taurolidine通过诱导小鼠黑色素瘤细胞(B16-4A5)凋亡,提高放射敏感性。方法:通过流式细胞仪检测不同浓度的taurolidine对B16-4A5细胞凋亡的影响;细胞克隆实验检测taurolidine的放射增敏性。结果:50μmol/L的taurolidine作用于B16-4A5细胞48 h,诱导12%的细胞凋亡,并显示了显著的时效和量效关系;细胞克隆存活实验显示,当25μmol/L的taurolidine与X射线联合时,细胞存活率开始降低,并随着药物浓度的增加,细胞存活率进一步下降,放射增敏比(SER D0和SER Dq)随着taurolidine的浓度增加而增加。结论:Taurolidine可能通过诱导B16-4A5细胞凋亡,提高放射敏感性。
作者 刘士新 孙宝胜
机构地区 吉林省肿瘤医院放疗二科
出处 《中国误诊学杂志》 CAS 2007年第30期7267-7268,共2页 Chinese Journal of Misdiagnostics
关键词 黑色素瘤 实验性/病理学 细胞凋亡/药物作用 噻二嗪类/药理学 牛磺酸/类似物和衍生物 动物 小鼠
分类号 R730.264 [医药卫生—肿瘤]
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参考文献7

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二级参考文献9

  • 1孙宝胜,刘晓岚,刘林林,傅士波,吴镇凤,龚守良.人参皂苷Rg3联合X射线照射对黑色素瘤细胞生长的抑制作用[J].吉林大学学报（医学版）,2006,32(6):1016-1018. 被引量：13
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共引文献3

同被引文献24

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中国误诊学杂志
2007年 第30期

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