取代嘧啶基硫脲类化合物的合成及生物活性

Synthesis and toxicity tests of the thiourea compounds

目的合成新的广谱、高效优良硫脲类杀菌剂。方法以氯甲酸酯与含不同取代基的嘧啶胺为原料,回流反应。结果合成了14个取代嘧啶基硫脲类化合物,其中12个化合物为首次报道的新化合物。结构组成经元素分析、IR及1H NMR确认,并测定了其对5种植物病菌的室内毒力作用。结论合成方法简便、易行,且大部分化合物具有良好的抑菌和杀菌活性。

Aim Synthesis of high effective and broad spectral new fungicides.Methods Using chloroformic ester reacted with biological substituted pyrimidinamine at reflux temperature to synthesize thiourea compounds.Results Fourteen new thiourea compounds were synthesized and twelve of them were new compounds.Their structures have been characterized by IR,^1H NMR and elemental analysis.Their fungicidal activities have been tested.Conclusion The experiments were easy to operate.The biological activity tests showed that most of them exhibited excellent biological activities.The relationship between the structures and the fungicidal activities of the compounds was discussed.