摘要
目的探讨在海拔3 700 m高原口服西地那非对肺功能的影响。方法选择驻守海拔3 700 m高原半年的10名志愿者,在其口服西地那非前、后0.5 h分别检测其肺功能。检测指标包括FVC,FEV1,FEV1%,MMEF,PEF和MVV。结果服药后与服药前0.5 h,肺功能指标分别为,FVC[(4.05±0.35)L vs(3.55±0.36)L],FEV1[(3.79±0.32)L vs(3.29±0.43)L],MMEF[(4.33±0.39)L/s vs(3.90±0.45)L/s],PEF[(5.77±0.79)L/s vs(4.80±0.92)L/s],MVV[(150.64±13.40)L vs(133.10±11.59)L]。服药后各指标显著高于服药前(P<0.01,或P<0.05),但FEV1%无明显变化(P>0.05)。结论在高原口服西地那非能提高移居者的肺通气功能。
Objective To explore the effect of Sildenafil on pulmonary function of incomers at 3,700 meters＇altitude.Methods Ten youths who had immigrated to a altitude of 3,700 meters half a year were tested on pulmonary ventilation half an hour before and after taking sildenafil,including FVC,FEV1,FEV1%,MMEF,PEF and MVV.Results After the intake of the medicine,the above parameters were increased significantly（P〈0.01,or P〈0.05）.Conclusion Sildenafil can improve incomers＇pulmonary function at high altitude.
出处
《临床军医杂志》
CAS
2007年第6期835-836,共2页
Clinical Journal of Medical Officers
关键词
高海拔
西地那非
肺功能
high altitude
sildenafil
pulmonary function
