经肝胆管切开引流术治疗晚期肝门部胆管癌

A Treatment Method to Advanced Hilar Cholangiocarcinoma:Bile Duct Incision and Drainage

目的探讨经肝胆管切开引流术对不能手术切除的肝门部胆管癌的临床疗效及应用价值。方法对2002年3月—2007年1月收治的9例不能切除的肝门部胆管癌,行经肝胆管切开置管引流术。结果9例手术经过顺利,总胆红素从术前的(312.9±161.8)mmol/L,下降为(176.1±80.8)mmol/L。血清丙氨酸氨基转氨酶从术前的(188.4±52.9)U/L下降为(56.9±17.3)U/L。5例获随访,病人平均存活时间14.7月。有1例病人已存活三年。结论不能手术切除的肝门部胆管癌病人行经肝胆管切开引流可有效地解除黄疸,改善肝功能,提高病人的生活质量,延长存活期。

Objective To evaluate the efficacy of bile duct incision and drainage for advanced hilar cholangiocarcinoma.Methods A retrospective analysis was performed with the data of nine patients who underwent bile duct incision and drainage for advanced hilar cholangiocarcinoma.Results Total bilirubin（TBIL） of the nine patients decreased to 176.1±80.8 from preoperative 312.9±161.8（mmol/L）,and GPT decreased to 56.9±17.3 from 188.4±52.9 U/L.Five patients were followed up.Their median survival time was 14.7 months,and one patient had been surviving for three years.Conclusion Bile duct incision and drainage can effectually relieve jaundice,improve hepatic function,enhance quality of life and prolong the survival time of the patients with advanced hilar cholangiocarcinoma.