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二甲双胍治疗年轻女性肥胖伴停经临床观察

Clinical study of metformin in young obese women with amenorrhea
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摘要 目的:观察二甲双胍对年轻女性肥胖伴停经的治疗效果。方法:选取年轻肥胖伴停经的女性患者40例,对照组16例,二甲双胍组24例。治疗8个月后观察体质量指数、腰围、血脂、血糖、胰岛素、C肽,血睾酮、促黄体生成素、促卵泡刺激素的变化。结果:在24例二甲双胍治疗组患者中有19例月经恢复,与对照组相比体质量指数、腰围、三酰甘油、血糖、胰岛素、C肽、睾酮、促黄体生成素均有改善,差异有显著性(P<0.05)。结论:二甲双胍对肥胖伴停经的女性有一定的治疗作用。 Objective: To investigate the effects of metformin in the treatment of young obese women with amen-orrhea. Methods: Forty patients were divided randomly into two groups: the treatment group(n = 24) and the control group(n = 16). The patients' correlative indexes( body mass index, waist circumference, lipid profiles, glucose, insulin, C-peptide, T, LH, FSH)were observed after 8 months treatment. Results. Recovery of menorrhea was found in 19 out of 24 patients treated with metformin. Body mass index, waist circumference, triglyceride, glu- cose, insulin, C-peptide, T, LH were improved (P 〈 0.05 ). Conclusion: Metformin had significant effect in young obese women with amenorrhea.
出处 《江苏大学学报(医学版)》 CAS 2007年第6期496-497,502,共3页 Journal of Jiangsu University:Medicine Edition
关键词 二甲双胍 肥胖 停经 metformin obesity amenorrhe
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参考文献6

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二级参考文献32

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