银杏酸对痤疮致病菌的抑制作用

Study on antimicrobial effect of Ginkgolic Acids against pathogenic bacterium of Acnes

目的:研究银杏酸对痤疮致病菌生长的影响。方法:以银杏酸同系物和3种单体为抑菌剂,对痤疮丙酸杆菌、表皮葡萄球菌进行抑菌试验,测定对细菌胞内酶的影响。结果:银杏酸对痤疮致病菌有良好的生长抑制作用,并造成痤疮丙酸杆菌门冬氨酸氨基转移酶外泄。结论:银杏酸可通过抑制痤疮致病菌生长对痤疮起到治疗作用。

Objective： To study the inhibition effects of ginkgolic acids against pathogenic bacterium of Acnes. Methods： To observe the growth of P. aches and S. epidermidis in culture medium containing ginkgolic acids and their three monomers, and to determine the concentrations of AST, LDH,CK and HB- DH in culture medium. Results： Ginkgolic acids exhibited a significative antibacterial activity against P. aches and S. epidermidis. The AST in P. acnes leaked out from the cell, after treated with ginkgolic acids. Conclusion： Ginkgolic acids had therapeutical effect to Acnes by exhibiting a significant antibacterial activity against P. acnes.