卵巢癌耐药性研究进展

Progress in mechanism of chemoresistance of ovarian cancer

卵巢癌是女性致死率最高的恶性肿瘤之一。化疗是非常重要的治疗手段。但是肿瘤的耐药性严重影响了治疗效果。最近的证据表明细胞凋亡和抗凋亡的关键途径异常是肿瘤耐药发生和发展的关键因素之一。此外，新发现的这些途径之间的相互作用表明肿瘤耐药可能是多因素的。归根结底，肿瘤细胞在化疗药物作用下的存亡，决定于这一细胞的整体凋亡能力。在本文中，我们就促进细胞生存的生化途径和它们如何调节细胞的药敏性进行讨论，最后得到一些新的研究方向，从而阐明基本的耐药机制。

Ovarian cancer is among the most lethal of all malignancies in women. While chemotherapy is the preferred treatment modality, chemoresistance severely limits treatment success. Recent evidence suggests that deregulation of key proand anti-apoptotic pathways is a key factor in the onset and maintenance of chemoresistance. Furthermore, the discovery of novel interactions between these pathways suggests that chemoresistance may be multi-factorial. Ultimately, the decision of the cancer cell to live or die in response to a chemotherapeutic agent is a consequence of the overall apoptotic capacity of that cell. In this review, we discuss the biochemical pathways believed to promote cell survival and how they modulate chemosensitivity. We then conclude with some new research directions by which the fundamental mechanisms of chemoresistance can be elucidated.