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FADD在帕金森病大鼠的表达及临床意义 被引量：1

Expression of FADD in PD rats and its clinical significinces
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摘要 目的研究FADD(Fas死亡结构域蛋白)在帕金森病大鼠模型中的表达,并探讨PD与死亡受体凋亡通路的关系。方法用免疫组化(THC)法检测30例健康雄性大鼠,随机分对照组6只和模型组24只。检测FADD的表达情况。结果帕金森病模型大鼠FADD表达上调,分别与对照组比较,组间差异有显著性(P<0.01),结论FADD表达异常在帕金森发病机制起着重要的作用,从而推断FADD介导的凋亡通路与帕金森病的关系。 Objective： To study the expression of FADD in the PD rats, and explore the relationship betwween PD and apoptosis. Method： Immunohistochemistry methed hibrization were used to detect the expression of FADD in30 rats who were individe into control（6 rats）groups and experlmental[ 24 rats ] groups. Result：the expression of FADD in PD rats is active comparing the control groups. All the defference are significant statistically in groups （P 〈0. 01 ）. Conclusion ：the incrrect expression of FADD is important to parkinson and conclude the relation of the FADDand parkinson.
作者 刘新红 谢安木 吴化民 秦丽晨
机构地区 青岛大学医学院 青岛大学附属医院 泰安市中心医院
出处 《泰山医学院学报》 CAS 2007年第2期116-119,共4页 Journal of Taishan Medical College
关键词 FADD 帕金森病 凋亡 FAS FADD parkinson apoptosis Fas
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献12

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共引文献25

同被引文献18

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泰山医学院学报
2007年 第2期

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