摘要
采用发散法合成了0.5～4.0代(G)聚酰胺-胺(PAMAM)树枝状高分子,通过薄层色谱分析产物组成,并进一步选用柱色谱法对半代产物进行了提纯与精制.用红外,核磁,高效液相色谱(HPLC)和热重分析等方法对提纯后产物进行了表征.结果表明,提纯得到的各PAMAM产物具有较完整的分子结构,小分子含量很少;且0.5GPAMAM产物HPLC测试纯度达到97.81%.
Polyamidoamine （PAMAM） dendrimers ranging from 0.5 to 4.0 generations（G） were synthesized via the divergent procedure. Additionally, PAMAM compounds of ester-terminal generations were analyzed by thin layer chromatography and purified by column chromatography on silica gel. The final products were characterized by F-FIR, NMR, HPLC and TG. The results showed that the structure of each PAMAM products was more perfect, and the small-molecule content was tiny. The HPLC purity of 0. 5G PAMAM was up to 97.81%.
出处
《化学研究》
CAS
2007年第4期41-44,共4页
Chemical Research
基金
江苏省卫生厅重点科研课题资助项目(wkj2006-2-024)
关键词
聚酰胺-胺
树枝状高分子
发散法
提纯
柱色谱
polyamidoamine
dendrimers
divergent
purification
column chromatography
