益心康泰对稳定型心绞痛冠心病患者血管内皮功能的影响

Effect of Yixinkangtai on blood vessel endothelial function in patients with coronary heart disease of stable angina pectoris

目的探讨益心康泰胶囊对稳定型心绞痛冠心病患者血管内皮功能的影响。方法稳定型心绞痛冠心病患者40例,正常健康组18例,采用随机、对照、单盲法将稳定型心绞痛冠心病患者分为益心康泰治疗组和常规治疗组各20例。益心康泰治疗组除心绞痛常规治疗外,加用益心康泰胶囊1.0g,3次/d口服;常规治疗组仅给予常规治疗。疗程均为30 d。治疗前后分别进行肱动脉血流介导性舒张功能(FMD)超声检测。结果治疗前益心康泰治疗组和常规治疗组的肱动脉反应性充血时内径舒张百分比均显著低于正常组(均P<0.05);益心康泰治疗组与常规治疗组比较,反应性充血时内径舒张百分比差异无统计学意义(p>0.05);疗程结束时益心康泰治疗组肱动脉反应性充血时内径舒张百分比显著高于常规治疗组(P<0.05)。结论心绞痛冠心病患者血流介导性舒张功能减退;益心康泰胶囊治疗后随着血流介导性舒张功能得到明显改善,心肌缺血显著减轻。说明内皮功能异常在心绞痛冠心病的发病中起重要作用。

Objective To study the effect of Yixinkangtai on blood vessel endothelial function in patients with coronary heart disease of angina pectoris. Methods The patients were randomly divided into Yixinkangtai group （ n = 20 ） and control group （ n = 20 ）, who were treated for 30 days as a course. The treatment group was treated with Yixinkangtai, 1.0 g each time and 3 times a day and control group was treated routinely only. Brachial vascular ultrasound was carried out for FMD before and after treatment. Results Diastolic percentage of internal diameter during reactive hyperemia was lower in treatment group than that in control group before treatment （ P 〈 0.05 ） but there was not significantly different after treatment,which was significantly higher in treatment group than that in control group after a course（ P 〈 0.05 ）. Conclusion FMD of coronary angina pectoris patients is degrading,but it will be improved and myocardial ischemia is improved also by Yixinkangtai treatment ,indicating that abnormal endothelial function plays an important role in the development of coronary angina pectoris.