2型糖尿病下肢血管病变炎症因子及丹参的干预作用

Analysis on Serum Levels of Inflammation Factors in Peripheral Vascular Disease and Type 2 Diabetes Mellitus and Influence of Salvia Miltiorrhiza

目的研究2型糖尿病下肢血管病变炎症因子及丹参对炎症因子的干预作用。方法将2型糖尿病下肢血管病变病人56例分为两组,对照组28例予以基础治疗,治疗组28例在基础治疗上加丹参治疗,另选糖尿病未合并下肢血管病变者20例为非治疗组。结果糖尿病合并下肢血管病变者炎症因子C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)明显高于非治疗组;治疗组治疗后炎症因子明显低于对照组。结论2型糖尿病下肢血管病变病人炎症因子明显升高,丹参能明显减低炎症因子。

Objective To analyse peripheral vascular disease with type 2 diabetes mellitus and study the effect of salvia mihiorrhiza on it. Methods Fifty- eight cases with diabetes and peripheral vascular disease were randomly divided into two groups： Salvia mihiorrhiza group（ n = 28）. Twenty cases with diabetes without peripheral vascular disease were assigned to controlled group. Results Compared with controll group, serum levels in the three cytokines of the diabetes cases with peripheral vascular disease were significantly elevated, and they were decreased in salvia mihiorrhiza - treatmont group. Conclusion Serum levels of the three cytokines （CRP, TNF - α, IL- 6）of the diabetes cases with peripheral vascular disease were significantly elevated, and salvia mihiorrhiza could treat the diabetes cases with peripheral vascular disease by reduce serum levels of the three cytokines （CRP,TNF- α, IL- 6）.