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近交系大、小鼠保种的研究

Studies on Maintenance of the Inbred Strains of Laboratory Mice and Rats
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摘要 本单位从1989年陆续引进了8个国际通用的标准近交系大、小鼠,通过5年多的繁殖和保种实践,我们根据每个品系的特点,逐渐摸索出一套科学的保种方法,设计了保种体系,保证了近交系大、小鼠的遗传质量。 Four inbred strains of mice and four inbred strains of rats had been introduced from Beijing since 1989, and maintained in our center. All of these strains, as foundation colonies, were kept according to a modified parallel line system with full brother-sister mating, accompanied with complete pedigree records including breeding record cards, pedigree charts and pedigree books. Up to now, all strains survived to 9~13 generations. We did not find genetic 'pollution', with the genetic testing method established by us.other data obtained were normal. The results showed that the method of maintenance is right.
出处 《实验动物科学与管理》 1997年第2期8-12,共5页 Laboratory Animal Science & Administration
关键词 近交系 大鼠 小鼠 保种 繁殖 医用实验动物 Inbred strain Mouse Rat Maintenance
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