乐友与米安色林治疗老年抑郁症对照研究

Compararive study of paroxetine and mianserin in the treatment of senile depression

目的:比较乐友与米安色林治疗老年抑郁症的疗效和安全性。方法:85例符合CCMD-3抑郁症诊断标准的老年患者,随机分为乐友组和米安色林组,治疗观察6周,采用汉密尔顿抑郁量表(HAMD)评定临床疗效,副反应量表(TESS)评定不良反应。结果:乐友组与米安色林组疗效相仿,疗后HAMD总分均有显著减少。乐友显效较快,不良反应较少。结论:乐友是治疗老年抑郁症的较好药物。

Objective：To compare the efficacy and safely of paroxetine and mianserin in the treatment of senile depression. Methods：Eighty five patients with senile depression were randomly divided into paroxetine and mianserim group, The period of study was six weeks. The efficacy was measured with HAMD. The side effects were assessed by the TESS. Results： The efficacy was similar between two groups. There were significant differences in the scores of HAMD before and after treatment in both groups, paroxetine took effect more quickly and had fewer side effects. Conclusions： paroxetine is an effective antidepressant in the treatment of senile deprdssion.