抗抑郁剂与丁螺环酮合用临床研究

The exploration to the additional efficacy of buspirone on antidepressant

目的:对抗抑郁剂合用丁螺环酮治疗抑郁的疗效进行临床研究。方法:符合CCMD-3抑郁症诊断标准的患者96例,使用抗抑郁剂治疗8周。将疗效不佳的48例分为两组,一组继续使用原抗抑郁剂治疗,另一组在原抗抑郁剂基础上合用丁螺环酮,疗程8周。以汉密尔顿抑郁量表(HAMD),副反应量表(TESS)评定疗效和不良反应。结果:8周合用组的(HAMD)评分均比各单用组明显下降。两组的TESS评分相仿。结论:丁螺环酮合用抗抑郁剂治疗抑郁症具有良好的协同疗效,不增加不良反应。

Objective ：To explore the addional efficacy of buspirone on antidepressant. Methods ：96 patients who met CCMD -3 criteria for depression were treated with antidepressants for 8 weeks,the48 patients of lower efficacy were divided into two groups. One wa combined buspiron with antidepressants, the other was still treated with original antidepressant. Efficacy and side effects were assessed with HAMD and TESS respectively. Results： The HAMD sores decreased significantly more in the combined group than that in those teeated with antidepressants only. There was no significant difference in TESS between two groups. Conclusions： Antidepressant combined with buspione is more effective in zhe treatment of depression, but the side are increased.