1Fotsis T, Zhang Y, Pepper. MS, et al. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses turnout growth [J]. Nature, 1994,368(6468) : 237-239.
2Cushman M, He HM, Katzenellenbogen JA, et al. Synthesis, antituhulin and antimitotie activity,and cytotoxieity of analogs of 2-methoxyestradiol,an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the eolebieine binding site [J]. J Med Chem,1995,38(12):2041- 2049.
3Park J, Franco RS, Augsburger JJ, et al. Comparison of 2-methoxyestradiol and methotrexate effects on non-Hodgkin's B-cell lymphoma [J]. Curr Eye Res,2007,32(7):659-667.
4Dingli D, Timm M, Russell SJ, et al. Promising preelinieal activity of 2-methoxyestradiol in multiple myeloma [J]. Clin Cancer Res,2002,8(12) : 3948-3954.
5Lin HL, Yang MH, Wu CW, et al. 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathwaymediated metastasis of gastric cancer [J]. Int J Cancer, 2007, 121 (11) : 2547-2555.
6Kinuya S,Yokoyama K,Koshida K,et al. Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy [J]. EurJ Nucl Med Mol Imaging,2004,31(7):981- 985.
7Casarez EV, Dunlap-Brown ME, Conaway MR, et al, Radiosensitization and modulation of p44/42 mitogen-activated protein kinase by 2-methoxyestradiol in prostate cancer models [J]. Cancer Res,2007,67(17):8316-8324.
8Mueck AO, Seeger H, Huober J. Chemotherapy of breast cancer-additive anticancerogenic effects by 2-methoxyestradiol [J]. Life Sci,2004,75(10) :1205-1210.
9Attalla H, Makela TP, Adlercreutz H, et al. 2- Methoxyestradiol arrests cells in mitosis without depolymerizing tubulin [J]. Biochem Biophys Res Commun, 1996,228(2) :467-473.
10Lottering ML,de Kock M, Viljoen TC, et al. 17beta-estradiol metabolites affect some regulators of the MCF-7 cell cycle [J]. Cancer Lett,1996,110(1-2) :181-186.