高原红细胞增多症患者T细胞亚群的观察

OBSERVATION OF T CELL SUBSETS OF HIGH ALTITUDE POLYCYTHEMIA

目的：为了研究高原红细胞增多症（HAPC）．患者细胞免疫功能，对9例HAPC患者的T细胞亚群从平原到高原进行了动态观察；方法：本研究采用间接免疫荧光法测定T细胞亚群；结果：在高原（海拔2260m）HAPC患者的OKT3+细胞明显低于正常人组（P＜0．01），而OKT4+／OKT8+比值与正常人组相比明显上升（P〈0．05）；HAPC患者进入平原（海拔10m）后10天，OKT3+细胞明显升高（P〈0．05），OKT4+／OKT8+比值显示有下降趋势；结论：上述结果提示，低氧可能是HAPC患者细胞免疫水平低下的诱因之一，其细胞免疫功能紊乱和失衡也许是HAPC许多病症的发生机理。

In order to study cellular immune function of high altitude polycythemia (HAPC),the T cell subsets in 9 cases of HAPC were observed by using kinetic detecting from high altitudeto plain. Method:The indirect immunofluorescent assay was used in the present study. Resucts:These results showed that in high altitude(2260m),the level of OKT3+ cells of HAPC was signif-icantly lower(P<0. 01)than that of normal population- The ratio value of OKT4+/OKT8+ in pa-tients with HAPC was significantly higher(P<0. 05) than that in normal person group. Byday 10after migrating from high altitude to plain(10m),the OKT3+ cell level of HAPC was significantlyrisen, and the ratio value of OKT4+/OKT8+ had a declinig tendency. Conclusion it is suggestedthat hypoxia probably is a cause for lower cellular immunity in HAPC,the disorder and imbalanceof cellular immune function perhaps take part in mechanisms for developing symptoms of HAPC.