剖宫产术预防性应用抗生素的对照试验

Clinical Observations on the Use of Antibiotics as Preventive Measure in Cesarean Section

对185例剖宫产病人采用不同方法应用抗生素预防术后感染的效果进行分组对比.手术前后短期用药组81例,采用术前24h至术后48h使用青霉素(或红霉素)全身用药加甲硝唑术中宫腔、盆腔局部用药.对照组104例,术后常规使用青霉素加甲硝唑静滴5～7h.两组术后病率分别为19.75%和48.08%(P<O.01);手术相关部位感染率分别是3.70%和26.92%(P<0.01).结果提示,手术前后短期用药预防感染的效果优于术后用药.

185 cases were divided into two groups in order to investigate the effect of antibiotics as preventive measure in cesarean section. 81 of them (group 1) were treated with venous dripping of penicillin (or erythromycin)for 24 h preoperatively and for 48 h postoperatively plus local use of metronidazole in the cavity of uterus and pelvis during operation. The other 104 patients (group 2) were routinely treated with venous dripping of penicillin and metronidazole for 5 to 7 days. The postoperative morbidity of the two groups were 19.75%(group 1) and 48.08%(group 2) respectively. The infections rates were 3.7% for group 1 and 20.92% for group 2 respectively. The P valuse of X2 test of both groups were less than 0.01. It was concluded that the effect of preoperative short term treatment with antibiotics is better than that of the postoperative routine use of antibiotics in the prevention of infection.