IUGR脐血中表皮生长因子水平的研究

Study of plasma epidermal growth factor concentrations in IUGR fetuses.

目的：从内分泌因素的角度对胎儿生长发育及其异常进行研究，以探讨ＩＵＧＲ与脐血中表皮生长因子（ＥＧＦ）水平的关系。方法：选择伴有ＩＵＧＲ的孕妇２２例及正常孕妇３８例，于分娩时抽取脐血，用放射免疫测定法（ＲＩＡ）测定ＥＧＦ水平，同时测定胎儿体重与胎盘重量，比较两组的差异。结果：正常体重儿（３４０９．１±２８４．７９ｇ）组的脐血ＥＧＦ水平（６２４．６４±７３．９０μｇ／Ｌ）明显高于低体重儿（２４０３．３±２７７．４１ｇ）组（２１７．９０±５４．５２μｇ／Ｌ）（Ｐ＜０．０５）；ＩＵＧＲ组胎盘重量３５４．３±９２．６４ｇ亦明显低于正常组的５４２．１±７８．３２ｇ（Ｐ＜０．０１）。结论：脐血中低ＥＧＦ水平是ＩＵＧＲ的相关因素之一，对妊娠过程中ＥＧＦ的作用及其机制进行研究有助于探讨ＩＵＧＲ病因及临床治疗。

Objective To investigate the role of EGF played in pathogenesis of intrauterine growth retardation(IUGR) fetuses. Methods Human epidermal growth factor(hEGF) concentrations in umbilical venous samples obtained from 22 IUGR and 38 appropriate for gestational age(AGA) fetuses were measured by specific homologous radioimmunoassay.The weights of fetuses and placentas were detected in the mean time. Results The mean concentrations of hEGF in plasma were significantly lower in IUGR fetuses than that in AGA fetuses(217.90±54.52μg/L vs 624.64± 73.90 μg/L, P <0.05).The mean weights of placentas were significantly lower in IUGR too(354.3±92.64g vs 542.1±78.32g, P <0.01). Conclusion These findings suggest that the patholgenesis in IUGR are associated with the lower plasma hEGF concentrations in umbilical vein.