固定化细胞的混合糖连续发酵动力学模型

Kinetic Model of Continuous Fermentation with Mixed Substrates by Immobilized Cells

利用固定化啤酒酵母和固定化毕赤酵母在两个串联的固定床内连续发酵由葡萄糖和木糖组成的混合糖制取酒精的过程，建立了连续发酵的非结构动力学模型。该模型以带抑制项的米氏动力学方程为酶动力学基础，考虑了抑制物抑制、底物抑制、轴向弥散及膜传质等因素。成功地引入了一个综合考虑颗粒相内外传质的总有效因子简化模型的计算。

An unstructured model was developed to simulate continuous ethanol fermentation with mixed substrates consisting of glucose and xylose,in which process, was operated in two cascade columns by immobilized Saccharomyces cerevisiae and immobilized Pichia stipitis CBS5773.The model was based on enzyme inhibition kinetics,taking into account substrate inhibition,xylose inhibition,axial diffusion and film diffusion.A total effectiveness factor was proposed considering both extra and intra particle diffusions to simplify the model calculation and a good agreement with experimental data was achieved.