布地萘德悬液氧驱雾化吸入治疗COPD急性加重的疗效观察

Observation of the effects of nebulized suspension in actue exacerbation of chronic obstructive pulmonary disease

目的比较雾化吸入布地萘德悬液与全身应用糖皮质激素治疗慢性阻塞性肺疾病(COPD)急性加重患者的疗效。方法55例COPD急性加重期患者随机分成观察组29例和对照组26例。观察组给予布地萘德悬液氧驱雾化吸入治疗5d,对照组不给予,两组均根据临床表现给予全身应用糖皮质激素治疗。观察两组治疗前后肺功能改善情况以及全身应用糖皮质激素治疗时间和剂量。结果观察组治疗5d后FEV1%增加了37%,与治疗前相比肺功能改善有显著性(P<0.05),而对照组相比差异无显著性。观察组全身应用糖皮质激素治疗时间缩短了3.7d,和对照组相比差异有显著性,使用激素(地塞米松的等效剂量)减少27.7mg,但和对照组相比差异无显著性。二组治疗后症状体征评分均较治疗前下降且差异有显著性(P<0.05);两组间比较差异无显著性。结论COPD急性加重患者同时给予雾化吸入布地萘德悬液能减少全身使用激素的剂量和使用时间。

Objective To compare the effects of nebulized budesonide suspension and systemic glucocorticiods on acute exacerbation of chronic obstructive pulmonary disease.Methods In 55 cases with acute exacerbation of COPD were divided into two groups,treated with 29 cases nebulized budesonide suspension and 26 cases systemic glucocorticoids.The treatment group were given nebulized budesonide suspension five days.Two groups were given systemic glucocorticiods.Observe the changes of pulmonary function before and after the treatment.The time of treatment and dosage of systemic glucocorticoids.Results After five days FEV1% improved 37% in the treatment group.It was different than before ,but has no difference with the comparison group.In the treatment group,treatment period of systemic glucocorticiods was short 3.7 days.It is difference with the comparison group.Although the dosage of glucocorticiods was reduced 27.7mg in the treatment group,but has no difference with the comparison group. The sign and symptom scores after treatment have decreased significantly than before and the decline have remarkable difference around the treatment.Difference between the two groups was not significant.Conclusion Nebulized budesonide suspension in treating acute esacerbation of chronic obstructive pulmonary disease can reduce the dosage of glucocorticiods and days.