冠心病患者冠状动脉不同程度狭窄时血脂、载脂蛋白和纤维蛋白原变化

The Changes of Serum Lipid,Apolipoprotein and Fibrinogen in Patients of Coronary Heart Disease with Various Extents Coronary Stenosis

对冠心病患者按冠状动脉狭窄程度不同分组，并与对照组相比较，测定血脂各组分和纤维蛋白原含量。结果显示，冠心病二亚组与对照组间血清总胆固醇无显著差异。冠心病二亚组甘油三酯、高密度脂蛋白胆固醇、载脂蛋白AⅠ、B、AⅠ／B、总胆固醇／高密度脂蛋白胆固醇、甘油三酯／高密度脂蛋白胆固醇及纤维蛋白原显著异常（P＜0．05或＜0．01）；其中甘油三酯、载脂蛋白AⅠ、高密度脂蛋白胆固醇、总胆固醇／高密度脂蛋白胆固醇、甘油三酯／高密度脂蛋白胆固醇及纤维蛋白原在冠心病冠状动脉明显狭窄组较轻度狭窄组改变更明显（P＜0．05）。提示上述参数可能对于区分冠心病患者有无有意义的冠状动脉狭窄具有一定的预示价值。

Aim To study the changes of serum lipid,Apolipoprotein and fibrinogen in patients of coronaryheart disease with various extents coronary stenosis.Methods According to the extents of angiographiccoronary maximal stenosis, 29 patients with coronaryheart disease (CHD) were classified (I ) obviousstenosis group (OSG, narrowing in luminal diameter>50% ), (Ⅱ ) mild stenosis) group MS. 16 non-CHDpatients proved by angiography served as controls(CG).Results There were no signifiant difference fortotal cholesterol (TC ) among the three groups.Triglyceride (TG), apolipoprotein (apoA I, apoB),high density lipoprotein cholesterol (HDLC), TC/HDLC, TG/HDLC, fibrinogen (Fg), apoA I / apoBin CHD patients were significantly abnormal as com-pared with CG (P<0.05 or P<0. 01, respectively). While TG, HDLC, apoA I, TC/HDLC, TG/HDLCand Fg in OSG changed significantly as compared withMSG.Conclusion TG, HDLC, apo AI, TC/HDLC,TG/HDLC and Fg related to the extents of coronarystenosis and may be of predictable values in coronarystenosis.