我院2005～2006年门诊麻醉性镇痛药利用分析

Utilization of Narcotic Analgesic Drugs in Outpatients of Our Hospital During 2005～2006

目的:评价我院门诊麻醉性镇痛药的利用情况。方法:对我院2005年8月～2006年8月门诊处方中麻醉性镇痛药的应用情况进行回顾性分析。结果:60a以上老年人中,癌症疼痛患者应用盐酸哌替啶注射液及所有麻醉性镇痛药的比例均明显高于非癌症疼痛患者(P<0.05);硫酸吗啡缓释片的药物利用指数(DUI)=1.32,枸橼酸芬太尼注射液和芬太尼透皮贴剂的DUI=1,磷酸可待因片和阿桔片的DUI分别为0.97和0.95,盐酸哌替啶、吗啡和布桂嗪注射液的DUI均明显<1。结论:盐酸哌替啶注射液及硫酸吗啡缓释片用于癌症疼痛治疗中存在不合理现象,应严格按照世界卫生组织推荐的《癌症三阶梯止痛指导原则》用药。

OBJECTIVE：To evaluate the utilization of narcotic analgesic drugs in outpatients of our hospital.METHODS： Narcotic analgesic drugs prescribed in outpatient prescriptions of our hospital from Aug .2005 to Aug .2006 were analyzed retrospectively.RESULTS：Among patients over 60 years old, the ratio of using pethidine hydrochloride injections and all narcotic analgesic drugs is significantly higher in those with cancer pain than those without（P〈 0.05） .The drug utilization index（DUI） of morphine sulfate sustained- release tablets was 1.32, that of fentanyl citrate injection or fentanyl transdermal system was 1; the DUI of codeine phosphate tablets and compound platycodon tablets were 0.97 and 0.95, respectively;the DUI of pethidine, morphine and bucinnazine hydrochloride injections were all less than 1（〈 1） .CONCLUSION：The application of pethidine hydrochloride injection and morphine sulfate sustained - release tablets for cancer pain relieving are far from rational. Three- step analgesic ladder program recommended by WHO should be strictly followed in treating patients with cancer pain.