二甲双胍在多囊卵巢综合征的作用

Effects of metformin on polycystic ovary syndrome

生殖及代谢异常是多囊卵巢综合征(PCOS)的特征性表现。已证实高胰岛素血症及胰岛素抵抗,导致血中雄激素水平过高,是PCOS的重要发病机制。二甲双胍(metformin)称为胰岛素增敏剂,用于治疗PCOS后,可减轻高雄激素血症,使月经周期规律,改善卵巢对诱导排卵的反应,提高妊娠率,降低早孕流产率,且能减低发展为II型糖尿病及心血管疾病的危险性。本文就国外近年有关metformin运用于PCOS的进展作一综述。

Polycystic ovary syndrome （PCOS） is characterized by reproductive and metabolic abnormalities. Hyperinsulinemia and insulin resistance which result in hyperandrogenemia have been documented as a central role in the pathogenesis of PCOS. Treatment with insulin sensitizer, metformin, has been shown to be followed by regularization of menstrual cycle, improved response to ovulation induction and reduction of hyperandrogenism. It possibly prevents early trimester pregnancy loss and decreases the risk of developing type Ⅱ diabetes and cardiovascular disease. This article aims to review the current evidence on the use of metformin in women with PCOS.