吲哚美辛栓联合曲唑酮治疗Ⅲ型前列腺炎的临床研究

Treatment of indomethacin suppositories with trazodone for patients with chronic abacterial prostatitis/chronic pelvic pain syndrome

目的探讨慢性非细菌性前列腺炎/慢性盆底疼痛综合征(CAP/CPPS)的治疗方法。方法对60例诊断为CAP/CPPS的患者使用非甾体类抗炎药直肠栓剂吲哚美辛栓及三唑吡啶类抗抑郁药曲唑酮进行8周的联合治疗。在治疗前、治疗后4周及8周对所有患者进行NIH-CPSI症状评分和EPS-WBC计数,对其中伴精液参数异常和性功能下降的患者分别进行精液参数测定和性功能评价。观察疗效及不良反应情况。结果60例患者在治疗后4周及8周NIH-CPSI评分和EPS-WBC较治疗前明显降低(P<0.001);伴精液参数异常和性功能下降的患者的射精潜伏期及IIEF-5评分较治疗前有明显改善(P<0.01);不良反应发生率较低。结论吲哚美辛栓联合曲唑酮的治疗方案安全有效,可以明显缓解CAP/CPPS患者症状,对患者精液质量及性功能亦有明显改善。

Objective To investigate a new effective treatment for chronic abacterial prostatitis/chronic pelvic pain syndrome（CAP/CPPS）. Methods 60 patients diagnosed as CAP/CPPS were given the therapeutic alliance with Indomethacin suppositories （NSAID rectal suppository） and Trazodone （triazole-pyridine antidepressant） for 8 weeks. All the patients were evaluated with NIH-CPSI symptom score and the counting of WBC of expressed prostatic secretion （EPS） at the time of pre-treatment, 4 weeks and 8 weeks after treatment. For those who had abnormal semen parameters and descended sexual function the semen parameters determination and sexual function evaluation were carried out separately. Therapeutic effect as well as side effect were observed. Results All the patients had an obvious decrease of NIH-CPSI score and EPS-WBC after treatment for 4 and 8 weeks than pre-treatment （P〈0.001）; the ejaculation latency period and IIEF-5 score show obvious improvement than pre-treatment （P〈0.01）. The incidence of side effect was low. Conclusion The therapeutic alliance of Indomethacin suppositories and Trazodone is safe and effective, it can manifestly relief the symptoms of CAP/CPPS, and can also improve the semen quality and sexual function, but the extended efficacy is not determined yet.