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CD4^+CD25^+调节性T细胞与肿瘤免疫 被引量：4

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摘要 CD4+CD25+调节性T细胞(CD4+CD25+Treg)是维持机体免疫耐受的一种重要因素。它组成性表达IL-2受体α链(CD25),主要的功能是抑制自身反应性T细胞的活化和功能,调节机体对抗原的免疫应答,从而使机体避免发生自身免疫病。近年来研究表明,Treg也可能通过相同的机制削弱机体的抗肿瘤效应。Treg介导的免疫抑制是肿瘤逃逸的原因之一。针对Treg进行肿瘤免疫治疗是一项可行的策略。
作者 陈惠娟 葛海良
机构地区 上海交通大学医学院上海市免疫学研究所
出处 《现代免疫学》 CAS CSCD 北大核心 2007年第6期508-511,共4页 Current Immunology
基金 国家自然科学基金资助项目(30572117)
关键词 CD4^+CD25^+调节性T细胞 肿瘤 免疫治疗
分类号 R392.1 [医药卫生—免疫学]
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参考文献24

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同被引文献17

  • 1张彩,田志刚.γ干扰素的负向免疫调节作用[J].现代免疫学,2007,27(2):89-92. 被引量：17
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  • 6Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells[J]. Nat Immunoel, 2003, 4:330-336.
  • 7Galli SJ, Kalesnikoff J, Grimbaldeston MA, et al. Mast cells as "tunable" effector and immunoregulatory cells: recent ad vances[J]. Ann Rev Immunol, 2005, 23:749-786.
  • 8Metz M, Maurer M. Mast cells-key effector cells in immune responses [J]. Trends Immunol, 2007, 28:234-241.
  • 9Depinay N, Hacini F, Beghdadi W, et al. Mast cell-dependent down regulation of antigen-specific immune responses by mosquito bites [J]. Immunology, 2006, 176: 4141-4146.
  • 10Boerma M, Fiser WP, Hoyt G, et al. Influenceofmast cells on outcome after heterotopic cardiac transplantation in rats [J]. Transpl Int, 2007, 20,256- 265.

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现代免疫学
2007年 第6期

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