精原干细胞龛境研究进展

Update of the Researches on the Niche for Spermatogonial Stem Cells

精原干细胞是一群能够自我更新并具有多向分化潜能的永生细胞。"干细胞龛"理论最初是在造血系统中提出来的,龛同样也存在于睾丸组织中。精原干细胞龛在睾丸中是半开放的隔离体系,具有特定的数量调控及随年龄变化的特征。两种内源性因子nanos2和Plzf调控精原干细胞自我更新。龛细胞分泌因子胶质细胞源性神经营养因子(GDNF)也调节精原细胞的更新。

Spermatogonial stem cells are a population of immortal cells, capable of self-renewal and multi-directional differentiation. The theory of the ＂stem cell niche＂ was originally proposed for the hematopoietic system, and niches also exist in testicular tissues. The niche for spermatogonial stem cells is a semi-isolation system, characteristic of specific number regulation and changing with the age. The self-renewal of spermatogonial stem cells is regulated by two endogenous factors, nanos2 and Plzf, as well as by the niche cell-excreted factor, glial-dervied neurotrophic factor （ GDNF）.