年轻妇女子宫内膜癌临床病理分析

Clinicopathological Study of Uterine Endometrial Carcinoma in Young Women

目的:探讨年轻妇女子宫内膜癌的临床病理特征,指导个体化治疗。方法:对15例年龄<40岁的年轻妇女子宫内膜癌(研究组)与同期的122例年龄≥40岁的子宫内膜癌(对照组)进行回顾性对照研究,比较两组的临床病理特征。结果:年轻妇女子宫内膜癌占同期子宫内膜癌总数的10.95%;研究组和对照组刮宫病理检查,未提示子宫内膜癌者所占比例,分别为13.33%和4.10%(P>0.05),Ⅰ型子宫内膜癌所占比例分别为93.33%和77.87%(P>0.05);研究组和对照组G1级所占比例分别为86.67%和48.36%(P<0.05),Ⅰ期所占比例分别为93.33%和61.48%(P<0.05);研究组雌、孕激素受体阳性率均高于对照组(P<0.05)。结论:年轻妇女子宫内膜癌具有不同于一般子宫内膜癌的临床病理特征,具有较好的预后因素,保守治疗有望改善其生活质量。

Objective：To investigate the clinicopathological characteristics of uterine endometrial carcinoma in young women,to help indMdualized therapy. Methods： 137 cases of uterine endometrial carcinoma in our hospital between 1996 and 2006 were recruited, among which 15 patients were less than 40 years old （study group）, and 122 patients were more than 40 years. Comparison was made regarding clinicopathological characteristics between the two groups. Results： 10.95% of endometrial carcinoma was young patients. 13.33% of the study group and 4.10% of the control group were not suggested as endometrial carcinoma by diagnostic curettage（ P〉 0.05） ,the percent of type Ⅰ were 93.33% and 77.87% respectively（P〉0.05） ,the percent of G1 期 were 86.67% and 48.36% respectively（ P〈 0.05）, the percent of stage Ⅰ were 93.33% and 61.48% respectively（ P〈 0.05） ;the expression of the estrogen receptor and progestogen receptor in study group were higher than that in control group（ P〈 0.05）.Conclusions：Young women with endometrial carcinoma had different clinicopathological characteristics and better prognosis compared to patients older than 40 years, conservative treatment would improve their quality of life.