摘要
帕金森病(PD)是常见的中枢神经系统变性疾病,其主要的病理特征为DA神经元的退行性病变,导致纹状体多巴胺含量降低。PD的发病机制仍不清楚,神经炎症在其发病过程中的作用备受瞩目,而小胶质细胞的激活作为神经炎症的主要组成部分更是发挥着不可忽视的作用,同时也有可能成为研究新型神经保护型抗PD药物的靶点。本文对小胶质细胞激活后对神经元发挥损伤作用的主要途径进行综述。
Parkinson＇s disease （PD） is a common neurodegenerative disorder, pathologically characterized by a progressive degeneration of dopaminergic neurons leading to dopaminergic deficiency in the striatum. Till now the pathogenesis of PD is unclear. However, neuroinflammation in PD becomes remarkable, in which the activation of microglia plays a predominant role, Moreover, the activation of microglia may be a target for developing new neuroprotective anti-Parkinson drugs. This review provides an outline of major effects of activated microglia on the neurons and its mechanism.
出处
《神经损伤与功能重建》
2007年第6期321-325,共5页
Neural Injury and Functional Reconstruction
关键词
帕金森病
小胶质细胞
神经炎症
Parkinson＇s diseases
microglia
neuroinflammation
