摘要
帕金森病（Parkinson’s disease，PD）是仅次于阿尔茨海默病的第二大神经系统退行性疾病，以静止性震颤、肌强直、运动迟缓和姿势障碍为临床特征。其病理特征为中脑黑质多巴胺能神经元选择性进行性变性缺失及胞质内包涵体Lewy小体形成。65岁以上人群中PD患病率约为1％-2％。大部分PD患者为散发病例，仅约10％-15％的PD病例呈家族性聚集。
出处
《神经损伤与功能重建》
2007年第6期355-358,共4页
Neural Injury and Functional Reconstruction
基金
国家自然科学基金项目(30570627)
参考文献24
-
1POLYMEROPOULOS MH, EAVEDAN C, EEROY E, et al.Mutations in the Alpha-synuelein Gene Identified in Families with Parkinson's Disease [J]. Science ( S0036 - 8075 ), 1997, 276:2045-2047.
-
2KITADA T, ASAKAWA S, HATTORI N, et al. Mutations in the Parkin Gene Cause Autosomal Recessive Juvenile Parkinsonism[J]. Nature(S0028 - 0836), 1998,392 : 605 - 608.
-
3LEROY E, BOYER R, AUBURGER G, et al. The Ubiquitin Pathway in Parkinson ' s Disease[J]. Nature (S0028 - 0836), 1998,395:451-452.
-
4POLYMEROPOULOS MH, HIGGINS JJ, GOLBE LI, et al. Mapping of Agene for Parkinson 's Disease to Chromosome 4q212q23[J]. Science(S0036-8075), 1996,274: 1197- 1199.
-
5KRUGER R, KUHN W, MULLER T, et al. Ala30Pro Mutation in the Gene Encoding Alpha-synuelein in Parkinson's Disease[J]. Nat Genet(S1061 -4036), 1998,18:106- 108.
-
6GASSER T, MULLERMYHSOK B, WSZOLEK ZK, et al. Genetic Complexity and Parkinson' s Disease [J]. Science (S0036- 8075), 1997,277: 388- 389.
-
7MATSUMINE H, SAITO MM, SHIMODA MS, et al. Localization of a Gene for an Autosomal Recessive form of Juvenile Parkinsonisrn to Chromosome 6q25. 2227[J]. Am J Hm Genet (S0002- 9291), 1997,60 : 588- 596.
-
8PRAMSTALLER PP, FALK M, SCHOENHUBER R,et al. Validation of a Mail Questionnaire for Parkinsonism in Two Languages ( German and Italian) [J]. J Neurol (S0340 - 5354), 1999,246 : 79-86.
-
9WINTERMEYER P, KRUQER R, KUHN W, et al. Mutation Analysis and Association Studies of the UCH-L1 Gene in German Parkinson' s Disease Patients [ J ]. Neuroreport (S1671-4083) ,2000,11(10) : 2079-2082.
-
10MELLICK GD, SILBURN PA. The Ubiquitin Carboxy-terminal Hydnolase-L1 Gene S18y Polymorphism Does Not Confer Protection Against Idiopathic Parkinson's Disease[J]. Neurosci Lett(S0304-3940), 2000,293(2):127-131.
同被引文献24
-
1罗叶容,巫纪英,黄连珠,李化机,陆玉枝.老年痴呆症护理者的心理调适[J].当代护士（中旬刊）,2005,12(2):61-62. 被引量：2
-
2李菲菲,费立鹏,阎德亮,孟梅,李兰英.首发精神分裂症病人家属心理问题与家庭干预的对照研究[J].现代护理,2005,11(1):10-12. 被引量：13
-
3冯洪,谢家兴,李秋红,张红云,邱红.脑卒中患者家属心理健康水平及其影响因素[J].中国康复理论与实践,2006,12(8):679-681. 被引量：13
-
4邹红,付莹,孔海燕.重症监护患者家属心理健康问题的调查研究[J].重庆医学,2007,36(8):761-763. 被引量：5
-
5常恩荣,胡建荣,刘爱英.肿瘤患者家属心理状态的健康教育干预[J].齐鲁护理杂志,2006,12(10B):2065-2066. 被引量：4
-
6Trend P,Kaye J,Gage H,et al.Short-term effectiveness of intensive multidisciplinary rehabilitation for people with Parkinson ' s disease and their carets.Clin Rehabil,2002,16 (7):717-25.
-
7Edwards NE,Scheets PS.Predictors of burden for caregivers of patients with Parkinson' s disease.J Neurosci Nurs,2002,34(4):184-90.
-
8Fernandez HH,Tabamo RE,David RR,et al.Predictors of depressive symptoms among spouse caregivers in Parkinson's disease.Mov Disord,2001,16(6):1123-5.
-
9Cousins R,Davies AD,Tumbull CJ,et al.Assessing caregiving distress:a conceptual analysis and a brief scale.Br J Clin Psychol,2002,41 (Pt 4):387-403.
-
10Caap-Ahlgren M,Dehlin O.Factors of importance to the caregiver burden experienced by family caregivers of Parkinson's disease patients.Aging Clin Exp Res,2002,14 (5):371-7.
-
1孟庆进,柴晓斌,胡国华.帕金森病后抑郁的最新研究进展[J].中国老年学杂志,2013,33(2):477-480. 被引量：16
-
2肖彬,郭纪峰,唐北沙.帕金森病相关蛋白的作用研究进展[J].脑与神经疾病杂志,2006,14(4):313-315.
-
3刘胜文,唐荣华,唐娜,黄露露.帕金森病并发抑郁的相关机制探讨[J].神经损伤与功能重建,2010,5(5):378-380. 被引量：1
-
4张海娜,陈秋惠,韩艳秋,胡国华.蛋白酶体抑制剂制备帕金森病模型的研究进展[J].山东医药,2008,48(37):107-109. 被引量：1
-
5毕铁琳,付秀娟,周翔宇.帕金森病的免疫学研究进展[J].中国老年学杂志,2013,33(16):4096-4097. 被引量：1
-
6张争辉,田荆华,刘胜.干细胞移植治疗帕金森病的实验研究进展[J].菏泽医学专科学校学报,2007,19(4):77-79. 被引量：1
-
7王兴全.从最新循证医学证据看帕金森病的治疗[J].中国老年保健医学,2010,8(1):32-35.
-
8陈晓鹏,崔桂云,沈霞.磁共振检测脑铁含量在帕金森病中的应用[J].临床神经病学杂志,2010,23(5):389-391.
-
9刘俊鹏,杨新玲.帕金森病氧化应激发病机制研究新进展[J].新疆医科大学学报,2013,36(3):292-295. 被引量：6
-
10卢芳,刘树民,杨婷婷.帕金森病的最新国内外研究进展[J].中国老年学杂志,2009,29(9):1171-1174. 被引量：37
