利多卡因血浆与唾液浓度的关系

Relationship between plasma and saliva concentrations of lidocaine

目的：研究利多卡因唾液浓度（Ｃｓ）与血浆浓度（Ｃｐ）相关性。方法：１０例健康志愿者（男性３人，女性７人）单次ｉｖ盐酸利多卡因（１ｍｇ／ｋｇ）后３０，６０，９０ｍｉｎ分别同时采取唾液及血液标本，用荧光偏振免疫分析法（ＴＤｘ）测定利多卡因浓度。结果：利多卡因唾液浓度与血浆浓度的相关性：（１）３０ｍｉｎ时Ｃｓ与Ｃｐ相关性不显著；（２）６０ｍｉｎ时，Ｃｓ＝０．４０３７＋０．９１９６Ｃｐ，ｒ＝０．６６３２Ｐ＜０．０５，Ｃｓ与Ｃｐ呈正相关；（３）９０ｍｉｎ时，Ｃｓ＝－０．２１６２＋１．５２９９Ｃｐ，ｒ＝０．９０６３，Ｐ＜０．０１Ｃｓ与Ｃｐ呈显著正相关。Ｃｓ／Ｃｐ比值Ｒ＝１．４６７±ｓ０．７０６（ｎ＝３０）。结论：当利多卡因血浆浓度为０．２７ｍｇ／Ｌ～０．９１ｍｇ／Ｌ时，其Ｃｓ与Ｃｐ呈正相关。利多卡因唾液浓度为血浆浓度的１．５倍。

AIM: To study the relationship between plasma and salvia concentrations of lidocaine. METHODS: Each of 10 healthy volunteers (M 3; F 7) received a single intravenous bolus of lidocaine (1 mg/kg). After iv a paired samples of saliva and blood were collected at 30, 60 and 90 min. Lidocaine concentration was determined by TDx method. RESULTS: The linear regression equations of lidocaine salivary (Cs) and plasma concentration (Cp) were: (1) at 30 min: Cs=1.0938+0.3719 Cp, n=10, r=0.2489, P>0.05. There was no correlation between Cs and Cp; (2) At 60 min: Cs=0.4037+0.9196 Cp, n=10, r=0.6632, P<0.05. There was a positive correlation between Cs and Cp; (3) At 90 min: Cs=-0.2162+1.5299 Cp, n=10, r=0.9063, P<0.01. There was a significant positive correlation between Cs and Cp. The ratio (R) of Cs/Cp was 1.467±s 0.706 (n=30). CONCLUSION: There is a correlation between salivary and plasma concentrations of lidocaine when lidocaine plasma concentration is 0.27 mg/L～0.91 mg/L. Lidocaine concentration in saliva is 1.5 times higher than that in plasma.