替硝唑治疗细菌性阴道疾病

Tinidazole in treatment of bacterial vaginosis

目的：观察替硝唑治疗细菌性阴道疾病（ＢＶ）的疗效。方法：细菌性阴道疾病７６例，随机分Ａ组４０例，首次口服替硝唑２ｇ，以后每２４ｈ服１ｇ，共７ｄ。Ｂ组为对照组３６例，用２％克林霉素阴道霜每晚睡前放置５ｇ，共７ｄ。另有并发泌尿系感染的ＢＶ４４例，其中２０例用替硝唑治疗的为Ｃ组，方法同Ａ组，２４例为Ｄ组，是在Ｂ组治疗的基础上加服诺氟沙星０．１ｇ，ｐｏ，ｔｉｄ。结果：Ａ和Ｂ组总有效率分别为９８％和６９％，Ｐ＜０．０１。Ｃ和Ｄ组总有效率分别为９０％和５４％，Ｐ＜０．０１。结论：替硝唑对单纯性ＢＶ和合并泌尿系感染的ＢＶ均有较好的疗效，仅有少数病人出现不良反应。

AIM: To verify the efficacy of tinidazole on bacterial vaginosis (BV). METHODS: The 76 patients with simple BV were divided into 2 groups: 40 patients (group A) received tinidazole 2 g po at the first dose, and then 1 g daily for 7 d; 36 patients (group B) received 5 g cream of 2% clindamycin in vagina hora somni for 7 d. Besides, 44 BV patients with urinary infections were also divided into 2 groups; 20 patients (group C) received tinidazole as group A, 24 patients (group D) received clindamycin as group B. RESULTS: The total effective rates of group A and B were 98% and 69%, respectively P<0.01, and those of group C and D were 90% and 54%, respectively P<0.01. CONCLUSION: Tinidazole is effective to BV.