活络化痰法对肺间质纤维化影响的实验研究

Empirical Study of Method of Activating Collaterals and Dissipating Phlegm on Pulmonary Interstitial Fibrosis

目的:观察活络化痰法对肺间质纤维化的作用。方法:选36只大鼠随机分为4组。A假手术组(9只)、B模型组(9只)、C中药治疗组(9只)、D西药治疗组(9只);C组予活络化痰中药水煎灌胃。28天后分离气管和双肺,称肺重,计算肺指数,并与其他各组进行对照观察。结果:中药治疗组、西药治疗组与模型组比较有显著差异(P<0.05);中药治疗组与西药治疗组相比较,无显著差异,但中药组大鼠体重、进食、状态均好于西药治疗组。结论:活络化痰法能降低肺间质纤维化程度。

Objective： To observe the effect of method of activating collaterals to dissipating phlegm on pulmonary interstitial fibrosis. Method： 36 rats had been chosen and divided into 4 groups. A group （including 9 rats） was as operation group, B group （including 9 rats） was as analogue group, C group （including 9 rats） was as TCM treatment group and D group （including 9 rats） was as western medicine treatment group. Intragastric administration was applied in C group with Chinese herbal decoction. After 28 days tracheae and lungs were separated, lungs weighed, lung indexes calculated and comparing observations among every group were done. Result. The differences between C and B, D and B group were significant （P〈0.05）. But there was not significance between C and D group. The rats＇ body weights, foodintakings and conditions in C group were better than those in D group. Conclusion. Method of activating collaterals and dissipating phlegm can decrease the rats＇ pulmonary interstitial fibrosis.