茶色素对冠心病病人血中超氧化物歧化酶及过氧化脂质的影响

Effect of tea pigment on serum superoxide dismutase and lipid peroxide in patients with coronary disease

目的：用随机双盲安慰剂对照法观察茶色素对冠心病病人血清超氧化物歧化酶（ＳＯＤ）及过氧化脂质（ＬＰＯ）的影响。方法：将病人分成２组，治疗组２２例服茶色素１粒（每粒１２５ｍｇ）ｔｉｄ×４ｗｋ，对照组１８例服安慰剂１粒，ｔｉｄ×４ｗｋ，并设健康人组作比较。结果：服茶色素后血清ＳＯＤ活力明显增高，由用药前的８７±ｓ１７μＵ／Ｌ上升至１０３±２５μＵ／Ｌ（Ｐ＜０．０１）；ＬＰＯ含量由用药前５．１±０．７μｍｏｌ／Ｌ降至４．０±１．１μｍｏｌ／Ｌ（Ｐ＜０．０１）与健康人的水平相当。对照组ＳＯＤ活力及ＬＰＯ含量用药前后无明显改变。结论：茶色素能改善冠心病病人血中ＳＯＤ活力及降低血清ＬＰＯ。

AIM: To evaluate the efficacy of tea pigment on serum levels of lipid peroxide (LPO) and superoxide dismutase (SOD) in patients with coronary disease. METHODS: Forty patients were randomized to receive tea pigment (22 patients) or starch (placebo, 18 patients). All were given po 125 mg tid for 4 wk. RESULTS: Tea pigments induced an increase in SOD activity from 87±17 to 103±25 μU/L(P<0.01) and a decrease in LPO levels from 5.1±0.7 to 4.0±1.1 μmol/L(P<0.01). No significant changes were found in placebo group. CONCLUSION: Tea pigments has some anti-lipid peroxidation effects and improves SOD activity and LPO levels in serum of patients with coronary disease.