摘要
目的：为探索西拉普利治疗高血压病疗效及其对胰岛素抗药性的影响。方法：采用随机对照法对原发性高血压３０例（男性１６例，女性１４例，年龄４８±ｓ１０ａ），用西拉普利２．５～５．０ｍｇ／ｄ，疗程４ｗｋ。对照组为２０例（男性１１例，女性９例；年龄５２±７ａ），用氢氯噻嗪２５～５０ｍｇ／ｄ，疗程４ｗｋ。结果：西拉普利和氢氯噻嗪都有明显降压作用，但只有西拉普利有改善胰岛素抗药性的效应。结论：西拉普利治疗高血压病人有改善胰岛素抗药性的作用，对糖代谢起良好的影响。
AIM: To study the effect of cilazapril on insulin resistance(IR) in patients with essential hypertension. METHODS: In a randomized and controlled design, cilazapril was used in a dosage of 2.5-5.0 mg once daily in 30 patients (M 16, F 14; age 48±s 10 a) with essential hypertension for 4 wk and was compared with that of hydrochlorothiazide (25-50 mg/d, for 4 wk) in 20 patients (M 11, F 9; age 52±7 a). RESULTS: Cilazapril and hydrochlorothiazide both showed decreases in blood pressure, but only cilazapril improved the IR. CONCLUSION: Cilazapril improves IR in essential hypertension and is beneficial on glucose metabolism.
出处
《新药与临床》
CSCD
北大核心
1997年第4期215-215,共1页
关键词
西拉普利
高血压
胰岛素抗药性
药物疗法
cilazapril
hypertension
insulin resistance
hydrochlorothiazide
