摘要
辣椒素(capsaicin,CAP)药理作用广泛,其对胃动力的影响已引起消化学者的关注.多数研究认为小剂量的CAP可促进胃动力,一定剂量范围的CAP可调节胃动力,而大剂量CAP对胃动力可能有抑制作用.CAP对胃动力的作用机制可能与CAP受体(vanilloid receptor subtype l,VRl)、P物质(SP)、乙酰胆碱、神经激肽A、生长激素释放肽和钙离子等有关.CAP可能成为一种有前景的胃动力新药.
Capsaicin has multiple pharmacological actions, and research has been centered on its effect on gastric motility. Most relevant studies have shown that low doses of capsaicin can accelerate, mediate, and high doses can inhibit gastric motility. The mechanism of action of capsaicin on gastric motility may involve vanilloid receptor subtype I （VR1）, substance P, acetylcholino, neurokinin A, ghrelin and calcium ions. Capsaicin has promise as a new drug for gastric motility disorders.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第31期3315-3319,共5页
World Chinese Journal of Digestology
关键词
辣椒素
胃动力
机制
Capsaicin
Gastric motility
Mechanismof action
