脑肠肽Obestalin与Ghrelin的研究进展

Research progress on brain-gut peptide obestatin and ghrelin

Obe statin与Ghrelin是两种重要的脑肠肽(brain-gut peptide,BGP),与其受体结合后发挥重要的生物学功能.Obestatin位于胃生长素前体原的76-98片段,可以结合孤儿G蛋白GPR39受体,抑制食物摄取、空肠的蠕动和体质量的增加.而Ghrelin则位于胃生长素前体原的24-51肽段,可以结合蛋白受体GHS-R,增加食欲和体质量,促进GH的释放,影响心血管功能和免疫机能等.Obestatin被认为是Ghrelin的生物学拮抗剂或阴阳活性多肽.

Obestatin and ghrelin are two important brain-gut peptides that can combine with their receptors and exert important biological functions. Obestatin is a 76-98 amino acid polypeptide segment of proghrelin that binds to the orphan G-protein-coupled receptor GPR39, which can suppress food intake, inhibit jejunal contraction, and decrease body-weight gain. Ghrelin is a 24-51 amino acid peptide segment of proghrelin that binds to receptor GHS-R, which can enhance appetite and body weight, promote the release of GH, and affect cardiovascular and immune functions. Obestatin is regarded as on biological antagonist, or a Yin and Yang activated polypeptide of ghrelin.