益肺抗瘤饮对肺癌转移及免疫功能的影响

Effect of Yifei Kangliu Yin on Lung Cancer Metastasis and Immune Function

目的：探讨益肺抗瘤饮对肺癌转移的抑制作用及其对免疫功能的影响。方法：（１）观察３组（９４例）肺癌患者远处转移灶，用放射免疫测定法测定患者的ＮＫ细胞。ＯＫＴ３、ＯＫＴ４、ＯＫＴ８值，并分组比较分析；（２）运用Ｃ５７小鼠Ｂ１６黑色素瘤模型观察益肺抗瘤饮对肺转移灶数的影响，并用免疫组织化学法观察转移灶周围Ｔ４、Ｔ８淋巴细胞的改变。结果：益肺抗瘤饮具有降低肺癌患者远处转移和减少Ｂ１６黑色素瘤肺转移的作用，而且益肺抗瘤饮能提高患者外周血ＮＫ细胞活性及ＯＫＴ３、ＯＫＴ４值，增加Ｂ１６黑色素瘤肺转移灶周围Ｔ４淋巴细胞的浸润。结论：益肺抗瘤位可能是增强了机体的免疫功能，调动患者自身的抗肿瘤能力，从而阻止癌转移的发生。

Objective:To explore the effect of Yifei Kangliu Yin (YFKLY) on metastasis of lung cancer and immune function. Methods: (1) Observing remote metastasis of three groups (n = 94) lung cancer patients, measuring the activity of NK cell, and the levels Of OKT3, OKT4 of the patients by radioimmunoassay, and duing compared analysis. (2) Observing the effect of YFKLY on C57 mice B16 melanoma, and examining T4, T8 around the foci of cancer metastasis by immunohistochemical method. Results: YFKLY significantly reduced the incidence of remote metastasis in patients and reduced the metastasis fool numbers on C57 mice of B16 melanoma. It was found that NK cell activities, OKT3 and OKT4 in peripheral blood of patients significantly increased, the infiltration of T4 lymphocytes around the fool of cancer metastasis also increased. Conclusion: YFKLY had inhibitory effect on the metastasis of cancer cells. It had strengthened the immune functions, aroused the anti-tumor capability.